NIH Will Stop Posting Notices of Funding Opportunities in the NIH Guide for Grants and Contracts in FY2026

Notice Number: NOT-OD-25-143

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-143.html

Purpose:

Since 2005, NIH has posted all grant and cooperative agreement notices of funding opportunities (NOFOs) in both Grants.gov, a federal-wide portal for discretionary funding opportunities, and the NIH Guide for Grants and Contracts (NIH Guide). Both have served as official sources for NIH NOFOs.

This Notice informs the extramural community that, beginning in fiscal year 2026, NIH will no longer post NOFOs in the NIH Guide. Grants.gov will serve as NIH’s single official source for grant and cooperative agreement funding opportunities. The NIH Guide will continue to be used for policy and informational notices.

This effort is part of a wider strategy across NIH to simplify and streamline the application and funding process and to reduce duplication across federal systems. 

What to Expect in FY2026

·        NIH NOFOs will no longer be accessible from the NIH Guide.

·      All NIH NOFOs (expired and active) will remain searchable on Grants.gov using their Classic search or their new Simpler search.

·     NOFOs will no longer be included in the weekly NIH Guide Table of Contents subscription emails. You can use Grants.gov subscription services to receive notifications of new NIH funding opportunities.

·      NIH will continue to provide tools in the Funding section of NIH Grants & Funding to identify potential funding categories, topics, and opportunities you may be interested in. Any funding opportunity identified through our site will link to Grants.gov for the official opportunity posting.

Resources

·         Updates to Finding NIH Funding Opportunities and Information

 Please refer to the full notice linked above for further details.

Should you have any questions, please contact the Office of Sponsored Programs.

Notice Number: NOT-OD-25-142

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-142.html

Purpose

This notice provides an update on the guidance issued in NOT-OD-25-110. Effective with the issuance of this Guide Notice, NIH has re-enabled the No-Cost Extension functionality within eRA Commons. Recipients may resume initiating first no-cost extensions in eRA Commons, in accordance with the NIH Grants Policy Statement, Section 8.1.1.3. Requests that were previously submitted via the prior approval module will not be reviewed, and recipients will need to initiate the first no cost extension within the Status module by using the Extension action.

Please refer to the full notice linked above for further details.

Should you have any questions, please contact the Office of Sponsored Programs.

Intro to the Financial Administrative Dashboards

NIH Announces a New Policy Requirement to Train Senior/Key Personnel on Other Support Disclosure Requirements

Notice Number: NOT-OD-25-133

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-133.html

Purpose

Background

This Guide Notice announces a new policy requirement that requires NIH recipients to provide training to all faculty and researchers identified as Senior/Key Personnel on the requirement to disclose all research activities and affiliations (active and pending) in Other Support (see Other Support form). The new requirement to train researchers to comply with other support disclosure requirements adds to the current policy (see NIH Grants Policy Statement (GPS), Section 2.5.1 "Just-in-Time Procedures") in order to provide a comprehensive plan in the area of disclosure requirements for recipients. This update will be included in the FY2026 version of the NIH GPS as part of NIH’s standard processes.

Effective October 1, 2025,  recipients must implement trainings, in addition to maintaining a written and enforced policy, on requirements for the disclosure of other support to ensure Senior/Key Personnel fully understand their responsibility to disclose all resources made available to the researcher in support of and/or related to all of their research endeavors, regardless of whether or not they have monetary value and regardless of whether they are based at the institution the researcher identifies for the current grant.

Please refer to the full notice linked above for further details.

Should you have any questions, please contact the Office of Sponsored Programs.

Supporting Fairness and Originality in NIH Research Applications

Notice Number: NOT-OD-25-132

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-132.html

Purpose

NIH is providing guidance to researchers on the appropriate usage of artificial intelligence (AI) to maintain the fairness and originality of NIH’s research application process. NIH is also instituting a new policy limiting the number of applications that NIH will consider per Principal Investigator per calendar year.

Background

NIH has recently observed instances of Principal Investigators submitting large numbers of applications, some of which may have been generated with AI tools. While AI may be a helpful tool in reducing the burden of preparing applications, the rapid submission of large numbers of research applications from a single Principal Investigator may unfairly strain NIH’s application review processes. The percentage of applications from Principal Investigators submitting an average of more than six applications per year is relatively low; however, there is evidence that the use of AI tools has enabled Principal Investigators to submit more than 40 distinct applications in a single application submission round.

NIH will continue to employ the latest technology in detection of AI-generated content to identify AI generated applications, but it is imperative that all NIH research applications are consistent with the NIH Grants Policy Statement (GPS) Section 2.1.2’s expectation that institutions and affiliated research teams propose original ideas for funding. AI tools may be appropriate to assist in application preparation for limited aspects or in specific circumstances, but researchers should be aware that using AI comes with its own risks. AI use may result in plagiarism, fabricated citations, or other kinds of research misconduct. As a reminder, NIH oversees research misconduct investigations and acts on non-compliance (see GPS Section 4.1.27).

Policy

NIH will not consider applications that are either substantially developed by AI, or contain sections substantially developed by AI, to be original ideas of applicants. If the detection of AI is identified post award, NIH may refer the matter to the Office of Research Integrity to determine whether there is research misconduct while simultaneously taking enforcement actions including but not limited to disallowing costs, withholding future awards, wholly or in part suspending the grant, and possible termination.

NIH will only accept six new, renewal, resubmission, or revision applications from an individual Principal Investigator/Program Director or Multiple Principal Investigator for all council rounds in a calendar year. This policy applies to all activity codes except T activity codes and R13 Conference Grant Applications. Based on recent data, this limit will affect a relatively small number of Principal Investigators while enabling the NIH to maintain consistently high-quality grant application review and appropriately steward taxpayer dollars.

Effective Date

This policy is effective for applications submitted to the September 25, 2025, receipt date and beyond.

 Please refer to the full notice linked above for details.

Should you have any questions, please contact the Office of Sponsored Programs.

-- Updated Implementation Guidance of NIH Policy on Foreign Subawards for Active Projects

Notice Number: NOT-OD-25-130

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-130.html

Purpose

As previously noted in NOT-OD-25-104, NIH must ensure it can transparently and reliably report on each dollar spent on foreign collaborations. The current subaward structure does not allow for consistent reporting and accurate tracking; therefore, NIH will not issue awards to domestic or foreign entities (new, renewal, or non-competing continuation) that include a subaward to a foreign entity. This Guide Notice updates the policy concerning existing projects and submitted applications.

Applicability

This Guide Notice addresses the implementation of the NIH Policy on Foreign Subawards (See NOT-OD-25-104) for applications submitted before May 1, 2025, and projects active on or before May 1, 2025.

 Please refer to the full notice linked above for further details.

Should you have any questions, please contact the Office of Sponsored Programs.

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-- Updated NIH Policy on Foreign Subawards

Notice Number: NOT-OD-25-104

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-104.html

Purpose

This Guide Notice updates NIH policies and practices utilizing foreign subawards. NIH recognizes that some recipients do not accurately report on subawards consistent with Federal Funding Accountability and Transparency Act (FFATA) subaward reporting requirements (NIH GPS 8.4.1.5.5), which state that recipients must report on all subawards/subcontracts/consortiums equal to or greater than $30,000. This includes awards that are initially below $30,000 but subsequent grant modifications result in an award equal to or greater than $30,000. This lack of transparency is particularly concerning in the case of foreign subawards, in which the United States government has a need to maintain national security.

In an effort to maintain strong, productive, and secure foreign collaborations in support of the NIH mission, NIH must ensure it can transparently and reliably report on each dollar spent. Therefore, NIH is establishing a new award structure that will prohibit foreign subawards from being nested under the parent grant. This new award structure will include a prime with independent awards that are linked to the prime that will allow NIH to track the project’s funds individually, while scientific progress will be reported collectively by the primary institution, under the Research Performance Progress Report. NIH anticipates implementing the new award structure by no later than September 30, 2025, prior to Fiscal Year 2026.

Please refer to the full notice linked above for further details.

Should you have any questions, please contact the Office of Sponsored Programs.