UMBC’s Lavik and team develop new approach to stop bleeding
Excerpt from "UMBC’s Lavik and Bieberich develop new approach to nanoparticles that stop internal bleeding"
SCIENCE & TECHNOLOGY | NOVEMBER 23, 2021 | MEGAN HANKS
When a person experiences a trauma that leads to significant bleeding, the first few minutes are critical. It’s important that they receive intravenous medication quickly to control the bleeding, but delivering the medication at the right rate can prove challenging. Slower infusions can cause fewer negative reactions, but the medication might not work fast enough, particularly in the case of a serious trauma.
Four UMBC researchers have developed a unique way of modifying the surfaces of nanoparticles within these life-saving medications to provide infusions that can be delivered more quickly, but with a reduced risk of negative reactions. Infusion reactions can cause a range of symptoms, such as rashes and inflammatory responses. This can include anaphylaxis, a life-threatening respiratory failure. Up until this point, the seriousness of these reactions has limited the use of promising nanomedicines, and reducing the likelihood of adverse reactions could be game-changing.
The core of the issue
In a paper recently published in
Nano Letters,
Erin Lavik, professor of chemical, biochemical, and environmental engineering; Chuck Bieberich, professor of biological sciences;
Nuzhat Maisha, Ph.D. ‘21, chemical engineering; and Michael Rubenstein, M.S. ‘14, Ph.D. ‘22, biological sciences, discuss their novel approach to the research. They focused on the core material of the nanoparticles delivered to patients.
“We found that using a polyurethane core reduced the markers associated with infusion reactions,” explains Lavik, who is also the associate dean for research and faculty development in UMBC’s College of Engineering and Information Technology.
Currently, 7% of people experience infusion reactions, the authors note in their paper. “These reactions…limit the treatments available in a substantial portion of patients,” they explain.
“We, like most of the field, have spent a lot of time trying to modify the surfaces of nanoparticles to modulate the reaction,” says Lavik. She shares that while that approach does help to a degree, going a step further by changing the core material appears to have a greater impact.
The research conducted by Lavik, Bieberich, and their colleagues lays the groundwork for future testing of preclinical models using nanocapsules to stop internal bleeding. Lavik explains that collaboration was an important element of this work, especially being able to conduct the research in UMBC’s Interdisciplinary Life Sciences Building.
]]>
Excerpt from "UMBC’s Lavik and Bieberich develop new approach to nanoparticles that stop internal bleeding" SCIENCE & TECHNOLOGY | NOVEMBER 23, 2021 | MEGAN HANKS When a person...
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faculty
grad
lavik
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Chemical, Biochemical and Environmental Engineering
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Mon, 06 Dec 2021 14:02:12 -0500
PhD Student Research Assistantship
Fall 2022 - AI & Theory-Oriented Molecular Science
A PhD student is sought for Fall 2022 to carry out a PhD project under Dr. Tyler Josephson's guidance on developing and applying molecular simulation techniques and artificial intelligence tools to gain molecular-scale insights on processes in the environment to enable new solutions for cleaner air and water.
Applicants should have a Masters or Bachelor’s degree in a related field and can apply to either the Environmental Engineering PhD program or the Chemical & Biochemical Engineering PhD program
Environmental Engineering PhD Program Overview
Applicant's prior coursework must include the completion of key prerequisites courses with a B or better. The prospective students must be admitted to the Environmental Engineering Doctoral program at University of Maryland, Baltimore County in the Department of Chemical, Biochemical and Environmental Engineering
Chemical & Biochemical Engineering PhD Program Overview
Applicant's prior coursework must include the completion of key prerequisites courses with a B or better. The prospective students must be admitted to the Chemical & Biochemical Engineering Doctoral program at University of Maryland, Baltimore County in the Department of Chemical, Biochemical and Environmental Engineering
Benefits:
Full-time PhD students admitted to the department are paid a stipend plus tuition remission and health insurance. The Fall 2022 PhD stipend is of $34,967/year.
Application Deadline: January 1, 2022
~~ UMBC is an EEO/AA employer. Individuals with disabilities, veterans, women and minorities are encouraged to apply. ~~
]]>
A PhD student is sought for Fall 2022 to carry out a PhD project under Dr. Tyler Josephson's guidance on developing and applying molecular simulation techniques and artificial intelligence tools...
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assistantship-2022
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environmental-engineering
fall-2021
grad
hennigan
phd
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Chemical, Biochemical and Environmental Engineering
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Chemical, Biochemical and Environmental Engineering
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0
true
Tue, 09 Nov 2021 07:33:54 -0500
Tue, 09 Nov 2021 07:34:27 -0500
PhD Student Research Assistantship
Fall 2022 - Air Pollution, Atmospheric Chem. & Aerosol Sci.
A PhD student is sought for Fall 2022 to carry out a PhD project under Dr. Chris Hennigan's guidance on Air Pollution, Atmospheric Chemistry, and Aerosol Science.
Applicants should have a Masters or Bachelor’s degree in a related field. Their prior coursework must include the completion of key prerequisites courses with a B or better. The prospective students must be admitted to the Environmental Engineering Doctoral program at University of Maryland Baltimore County in the Department of Chemical, Biochemical and Environmental Engineering. Environmental Engineering PhD Program Overview
Benefits:
Full-time PhD students admitted to the department are paid a stipend plus tuition remission and health insurance. The Fall 2022 PhD stipend is of $34,967/year.
Application Deadline: January 1, 2022
~~ UMBC is an EEO/AA employer. Individuals with disabilities, veterans, women and minorities are encouraged to apply. ~~
]]>
A PhD student is sought for Fall 2022 to carry out a PhD project under Dr. Chris Hennigan's guidance on Air Pollution, Atmospheric Chemistry, and Aerosol Science. Applicants should have a...
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grad
hennigan
phd
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Chemical, Biochemical and Environmental Engineering
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0
true
Thu, 21 Oct 2021 13:49:06 -0400
Fri, 05 Nov 2021 09:45:23 -0400
Masters Student Trainee opportunity in the urban environment
FALL 2022
UMBC is seeking applicants in the following areas for urban environmental work:
Masters Student Traineeships - iCARE
The
iCARE NRT master’s degree is a 2-year interdisciplinary degree program with a dual mission of diversity, equity, inclusion, and justice combined with research focused on improving the health of Baltimore Harbor as a socioecosystem. Students will be mentored by a UMBC faculty member and a non-academic scientist from a government agency, non-profit, or industry. That research team will be embedded in a larger stakeholder team, meaning that each student and their mentors will identify one or more community members (non-scientists) with a stake in the research to be engaged in the research from development to completion.
Students will also be taking skills courses (community leadership, DEIJ, oral and written communication) and disciplinary courses appropriate to their research project.
Graduate students in our program will follow a two-year schedule that includes a series of professional and disciplinary courses, plus a research project that will comprise their master’s thesis. For the research project, students will be mentored by a team that includes at least one faculty member and one partner practitioner working on projects related to the Baltimore Harbor and surrounding environments.
Student Benefits Include:
- $34,000 annual stipend, full tuition coverage, fees, & health insurance.
- Up to $7,500 in research expenses.
- Mentoring and networking with employers across the environmental sector.
Students should apply to any of the five main departments at UMBC affiliated with the program: Biological Sciences; Chemical, Biochemical and Environmental Engineering; Geography and Environmental Systems; Marine Estuarine Environmental Sciences; or the School of Public Policy. They should also separately complete a short application to the ICARE program, available to view on our website here:
https://icare.umbc.edu/application/.
Here is a link to a
series of slides that describes what each of the ICARE faculty do especially with respect to the ICARE master's program.
Please pass this information on to prospective students and encourage them to contact us and complete the
ICARE Interest Form.
Students need to apply to their respective program at this
link and complete a supplemental
ICARE NRT application by
January 1, 2022 for the
Fall 2022 cohort.
Potential Environmental Engineering Mentors:
-
Lee Blaney - contaminants of emerging concern & resource recovery
-
Upal Ghosh - analysis and remediation of toxic pollutants in soils and other environments
-
Brian Reed - removal of inorganic contaminants from the aqueous phase by activated carbons
-
Christopher Hennigan - Processes governing atmospheric chemistry and aerosol pollution
-
Claire Welty - quantify and predict the urban hydrologic cycle and coupled biogeochemical cycles from neighborhood to regional scales
]]>
UMBC is seeking applicants in the following areas for urban environmental work: Masters Student Traineeships - iCARE The iCARE NRT master’s degree is a 2-year interdisciplinary degree program...
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cuere
fall-2021
ghosh
grad
hennigan
ms
reed
research
welty
Chemical, Biochemical and Environmental Engineering
https://my3.my.umbc.edu/groups/cbee
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Chemical, Biochemical and Environmental Engineering
0
0
true
Wed, 20 Oct 2021 14:55:58 -0400
Mon, 06 Dec 2021 14:22:14 -0500
Dr. Kafui Dzirasa named National Academy of Medicine member
National Academy of Medicine Class of 2021
Dr. Kafui Dzirasa ‘01, M8, chemical engineering, recently earned two highly prestigious honors distinctive even among leaders in the medical and life sciences: an HHMI Investigator award and election to the National Academy of Medicine.
Dzirasa is the K. Ragna Rama Krishnan Associate Professor of psychiatry and behavioral sciences at Duke University. He earned both his MD and his PhD in neurobiology and neurosciences at Duke. Today, he examines the role of the brain’s electrical activity in psychiatric illness, including depression, bipolar disorder, and addiction, with the goal of creating mechanisms to disrupt these disorders.
Achievement and service
Dzirasa is one of 100 new members
elected to the National Academy of Medicine this year. The announcement recognizes his “seminal contributions to the neuroscience of emotion and mental illness” as well as his pioneering research methods. It also honors his “contributions to society through science policy and advocacy, a commitment to mentoring, and support for efforts to build a diverse and inclusive scientific workforce,” carrying forward the values of UMBC’s Meyerhoff Scholars Program.
Election to the National Academy of Medicine recognizes leaders in health and medicine who have demonstrated both outstanding professional achievement and a commitment to service. The National Academy of Medicine has more than 2,200 elected members worldwide, with new members limited to 100 per year.
]]>
[Excerpt from UMBC alumnus Kafui Dzirasa is named an HHMI Investigator, elected to the National Academy of Medicine] Dr. Kafui Dzirasa ‘01, M8, chemical engineering, recently earned two highly...
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award
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Chemical, Biochemical and Environmental Engineering
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Chemical, Biochemical and Environmental Engineering
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0
0
true
Wed, 20 Oct 2021 10:59:28 -0400
Tue, 26 Oct 2021 13:49:11 -0400
Dr. Upal Ghosh gives GRIT-X talk for 2021 UMBC homecoming
Saving our environment from the past: chemicals and fish
The annual GRIT-X talks returned for UMBC homecoming as eight UMBC community members, including Dr. Upal Ghosh, Professor, Chemical, Biochemical and Environmental Engineering. He joined three other CBEE faculty members and one CBEE alumnus as distinguished presenters at the GRIT-X talks since it’s inception in 2016.
His talk explored his work in understanding toxic pollutants and how they impact the environment. Even though some of the pollutants were banned from use 50 years ago, these contaminants can still be found in fish and wildlife today. Ghosh’s work also includes creative approaches to removing dangerous pollutants from waterways so they can’t cause further harm.
]]>
The annual GRIT-X talks returned for UMBC homecoming as eight UMBC community members, including Dr. Upal Ghosh, Professor, Chemical, Biochemical and Environmental Engineering. He joined three...
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faculty
fall-2021
ghosh
research
talk
Chemical, Biochemical and Environmental Engineering
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Chemical, Biochemical and Environmental Engineering
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0
true
Wed, 20 Oct 2021 10:48:27 -0400
Fri, 05 Nov 2021 09:46:43 -0400
UMBC finalists for the Rapid Testing Innovation Award
At Advanced Lateral Flow Conference 2021
The team led by UMBC's Dr. Dipanjan Pan (twitter: @ProfDipanjanPan) is the only academic group selected as a finalist for the Rapid Testing Innovation Award at the Advanced Lateral Flow Conference 2021.
Rapid Detection of SARS-CoV-2 via Oligonucleotide Based Molecular Lateral Flow Assay
Presented by Ketan Dighe
During the COVID-19 pandemic’s early and deadliest days last year, health authorities were plagued by a lack of testing, long wait times for results, and an ambiguous picture of what was generating outbreaks. Many public health experts are still dealing with the same challenges more than a year and a half later into the pandemic. Therefore, the need of the hour is a self-administered test that is accurate, simple-to-run, and detects COVID-19 cases within minutes. Here we develop a direct POC lateral flow assay devoid of an RNA isolation and amplification step to detect positive COVID-19 cases within 10 minutes.
]]>
The team led by UMBC's Dr. Dipanjan Pan (twitter: @ProfDipanjanPan) is the only academic group selected as a finalist for the Rapid Testing Innovation Award at the Advanced Lateral Flow Conference...
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award
fall-2021
pan
research
Chemical, Biochemical and Environmental Engineering
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Chemical, Biochemical and Environmental Engineering
4
0
true
Mon, 11 Oct 2021 11:19:24 -0400
Wed, 10 May 2023 10:21:47 -0400
POST DOCTORAL POSITION IN AEROSOL MULTI-PHASE CHEMISTRY
PI: Dr. Hennigan
One postdoctoral research associate position is available starting early 2022 in the Department of Chemical, Biochemical, and Environmental Engineering at the University of Maryland, Baltimore County. The selected candidate will be expected to work with Dr. Chris Hennigan on a DoE-funded research project focused on atmospheric multiphase chemistry. The project will characterize light-absorbing organic compounds (brown carbon) in atmospheric cloud water. The candidate will be expected to work closely with a Ph.D. student and undergraduate students, and to help in the training and mentoring of the students. The employee will also assist in drafting project reports, making presentations, writing new proposals, and drafting publications. Candidates with a PhD in Environmental Engineering, Chemical Engineering, Chemistry, or Environmental Science are preferred. Research experience in one or more of the following fields is desirable: aerosol chemistry, atmospheric trace gas measurements, organic aerosols, and environmental analytical chemistry.
Review of applications will begin December 1, 2021 and will continue until the position is filled.
Interested candidates should send a cover letter highlighting their relevant experience and research interests, curriculum vitae, and a list of three references as a single .pdf to Dr. Chris Hennigan (hennigan@umbc.edu).
~~ UMBC is an affirmative action/equal opportunity employer. ~~
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One postdoctoral research associate position is available starting early 2022 in the Department of Chemical, Biochemical, and Environmental Engineering at the University of Maryland, Baltimore...
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CBEE alumnus, Dr. Kafui Dzirasa named as HHMI Investigator
CBEE alumnus, Kafui Dzirasa, MD, PhD, '01 chemical engineering, has been named to the newest class of 33 HHMI Investigators! This is tremendous achievement for Dr. Dzirasa and his research team, and marks the first HHMI appointment for a UMBC Meyerhoff Scholar alum. New Investigators receive roughly $9 million over a seven-year term, which is renewable pending a successful scientific review and were selected from more than 800 eligible applicants.
“HHMI is committed to giving outstanding biomedical scientists the time, resources, and freedom they need to explore uncharted scientific territory,” says HHMI President Erin O’Shea.
Dr. Dzirasa (M9) visits UMBC once a month to mentor and engage with current
Meyerhoff Scholars.
For more details, please read the HHMI press release found on this
link.
"A pioneering breakthrough may come from chemist and bioengineer Dipanjan Pan, who is currently looking into a melittin-based cancer therapy with his lab at the University of Maryland, Baltimore County and University of Maryland School of Medicine.
Amid calls for safer, more successful cancer treatments, Pan inspected toad, scorpion and bee venom for answers. “The philosophy of my research is biomimetics, or bringing inspiration from Mother Nature,” he says.
These animal poisons include toxins like melittin, which is considered a host defense peptide. Most multicellular organisms have these peptides to ward off disease, including humans, but only some creatures weaponize them in the form of powerful venom. Funnily enough, this toxin could end up saving human lives.
And it isn’t particularly difficult to create synthetic melittin in a lab, Pan says, which is optimal for drug development due to its convenience, quality control, and relative safety compared to crude natural sources.
The real challenge: designing an effective delivery method that squashes cancer growth but leaves surrounding cells healthy. Chemotherapy, for example, commonly causes patients to lose their hair because it damages follicles in the process. “That has been the key bottleneck in targeted [cancer] therapy,” he adds. “It boils down to: How can we make these venom peptides more selective and targeted to the cancer cell? It’s like finding a needle in a haystack.”
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Discovery Magazine interviewed Dr. Dipanjan Pan about lab's research on venom as a possible cancer therapy. Excerpt from All the Buzz About Bee Venom (and More) "A pioneering breakthrough...
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