Characterizing Zincergic Neuron Projections and Elucidating their Role in Cocaine Mediated Behaviors

Location: Poster #52 from 10-11:30am in the UC Ballroom

Leila Ghaffari
Mentor: Michael Michaelides, NIDA

Zinc (Zn2+) is an essential element of life that regulates neurophysiological homeostasis. Additionally, zinc has been understood to enhance the affinity for cocaine binding of the dopamine transporter (DAT), resulting in the enhancement of cocaine mediated behaviors. Synaptic, or free zinc, has also shown to be an endogenous modulator of dopamine neurotransmission in the striatum. It is not known, however, how zinc affects DAT activity between males and females, and whether such activity differs between the dorsal striatum and nucleus accumbens, or in regions where zincergic neurons originate. Our project aims to increase understanding of zinc in this context. First, we assess whether zinc affects cocaine related behaviors, known to be modulated by striatal activity following striatal zinc chelation. Our next goal is to study if zinc alters DAT and dopamine D1 receptor binding as a function of sex. Our third goal aims to understand the proportion of zincergic neurons that project to the striatum. Through these research goals, our hope is to characterize zinc as it affects sex-dependent dopamine neurotransmission in striatal circuits.

See the full URCAD schedule at: URCAD.umbc.edu

Morning Session: 10 – 11:30 a.m. UC Ballroom Lounge

Afternoon Session: 1 – 2:30 p.m. UC Ballroom Lounge

Join us on Wednesday at 12 noon in UC 312 for the URCAD Keynote by Alicia Wilson (UMBC, Political Science, '04).

Alicia L. Wilson, Esq. is the Managing Director and Global Head of Philanthropy for the North America Region for JPMorgan Chase. At JPMorgan, Alicia oversees the local philanthropic strategies across 40+ markets in North America, collaborating intentionally with senior leaders across the firm’s corporate responsibility and business units to drive meaningful impact across JPMorgan’s business footprint in the U.S. and Canada. This includes helping to steward the $2 billion philanthropic commitment as part of the firm’s broader Racial Equity Commitment.

Prior to joining JPMorgan, Alicia served as Vice President of Economic Development for Johns Hopkins University and Johns Hopkins Health System and Associate Professor in the Johns Hopkins Bloomberg School of Public Health, in Baltimore, Maryland. At Johns Hopkins, Alicia led a core cross-institutional team focused on developing and implementing Hopkins’ institution-wide strategies and initiatives as an anchor institution in and around its campuses both within the United States and abroad. Alicia spearheaded the elevation and expansion of Hopkins signature commitment to its communities through investments in real estate, economic and neighborhood development, healthcare, and education.

Alicia is a graduate of the University of Maryland Baltimore County (UMBC, 2004) and the University of Maryland Francis King Carey School of Law. At UMBC, Wilson was a Blaustein and Sondheim Public Affairs Scholar and, in 2003, was named the Harry S. Truman Scholar for the state of Maryland. She worked closely with Dr. Roy Meyers (retired professor, Political Science). Alicia was named the inaugural 2004 Andrew Levy Leadership Scholar at the University of Maryland School of Law. In late 2004, she was also named the 2004 George L. Russell Scholar at the School of Law. While in law school, Alicia served as the co-captain of the Maryland Law National Trial Team and led her team to be ranked the number one trial team in the country.

Alicia is actively involved in civic and charitable organizations. She is a native of Baltimore City and valedictorian of her class at Merganthaler Vocational-Technical High School and draws on her experiences growing up in inner-city Baltimore for inspiration to help others realize their dreams. She currently serves on the boards of Johns Hopkins University, the University of Maryland School of Law Board of Visitors, the CollegeBound Foundation, Kennedy Krieger Institute, and the France-Merrick Foundation. She is also co-founder of the Black Philanthropy Circle at the Baltimore Community Foundation. Alicia is also Chair of the CollegeBound Foundation and as such is the first CollegeBound Foundation alum, first woman, first African-American and youngest Board Chair in the thirty history of the organization. Alicia also serves as Parliamentarian within the Harbor City Chapter of the Links, Incorporated and is a proud member of Delta Sigma Theta Sorority, Incorporated.

For her accomplishments and public service, Alicia has received over fifty professional awards and honors. Most recently, Alicia was recognized as Pro Bono Partner of the Year for 2022 by the Equal Justice Council and was selected as the 2022 Whitney M. Young Award recipient for her service to youth by the Boys Scouts of America, Baltimore Area Council.

Her professional and civic leadership have propelled her to the forefront of local and national media attention. Most recently, Alicia was recognized as one of the 15 Black Marylanders to Watch for 2023 by the Baltimore Sun. In mid-2022, Savoy Magazine recognized Alicia as one of the “Most Influential Black Executives in Corporate America”. She was also named a 2022 “Women Who Wins” and Newsmaker of the Year for 2021 by the Afro-American Newspaper.

This post was orginially written and posted on April 22nd, 2019 by Sambam226. 

April is Sexual Assault Awareness Month, and the Women’s Center is hosting its 7th consecutive Take Back the Night on Thursday, April 13th. Over the years, we’ve had a lot of questions about what Take Back the Night exactly is, why it looks the way it does, and how students can get involved. To help get those questions answered we started the “What You Need to Know” series focused on TBTN last year and are continuing on the tradition, so stay tuned for more posts over the next week. This is an updated post to last year’s information focusing on the survivor speak-out.

The survivor speak-out is the heart of Take Back the Night. This is the point in the night where survivors are encouraged to come up and share their story with the crowd before the march throughout campus. As a survivor, sharing your story at TBTN allows you to publicly acknowledge your experience with a crowd that believes you and supports you.

Kayla Smith, UMBC Class of 2017, started the speak out in previous years and cherished that moment as a time where she could share her experience with people who she knew wouldn’t judge her. She could look out into a crowd of people who wouldn’t tell her its her fault, ask what she was wearing, ask if she was drinking, or tell her that she was responsible for her assault. “Speaking out about my assault empowers me to talk about my experience with confidence.”

This year we want to focus on dispelling the myth of the “perfect victim” that often times dominates sexual violence discourse. There are a variety of stories and experiences that are shared during the speak- out. Some may share stories or healing while others are still angry, sad, or scared. Many stories may come from women-identified folks and/but male survivors are also invited to share their stories at the speak-out. All of our stories and experiences are valid. And, no matter where you are at in your experience as a survivor (i.e. your assault happened 10 years ago or just last week) or what your identities may be, you’re welcomed to share your story.   

If you’re thinking about speaking at Take Back the Night, feel free to reach out to Women’s Center staff ahead of time if you feel like it would be helpful to talk to someone ahead of time about your story and how you may want to share it. Of course, we know many survivors may not plan on speaking at TBTN and then feel called to do so once the speak-out begins and that’s okay! If you feel uncomfortable sharing during the speak-out, that’s also 100% okay! There will be a chance to be recognized during the March at the Survivor Circle (which will be a new part of this year’s march – stay tuned for our updated What You Need to Know about the March post for more details!) or discuss your experience in a more intimate setting at We Believe You’s survivor discussion group post march.

It’s also totally okay if don’t feel ready to share your story at Take Back the Night – there’s many other ways you can share your story in less public ways throughout Sexual Assault Awareness Month (like making a t-shirt for the Clothesline Project or the other ways at TBTN we mentioned in the above paragraph) and Take Back the Night (counselors will be available throughout the event and there will be the self-care station). Survivors or anyone impacted by sexual violence can also always schedule a time to talk to Women’s Center staff – we’re quasi-confidential resources on campus and can link you to additional support and resources.

Here’s some helpful information about the speak-out we think is helpful for everyone to know whether they’re speaking or listening:

• Any one can be a survivor of sexual violence. Any survivor regardless of their gender identity or sexual orientation is welcomed to share their story at the speak-out. At the beginning of TBTN’s creation the speak out was only for women, but we welcome men and all others who may have differing gender identities to speak out. We wish for the speak out to be an inclusive space of healing and representation of different identities can help dispel the dangerous “perfect victim” narrative.
• The survivor speak-out is intended to center the voices and experience of survivors of sexual violence. The speak-out is for allies to listen and survivors to break their silence. Thank you in advanced for respecting this request. Allies are also encouraged to attend the Women’s Center workshop on Supporting Survivors of Sexual Violence on 4/11. 
• Since TBTN functions as a public forum, normal reporting procedures look a bit different. If you choose to share your story, and want to go no further in the reporting process, we encourage you not to disclose any names or other specific identifying information, such as locations or familial relationships, as those details may prompt staff to follow up with you for reporting matters. Staff are available at the event for those who do want additional resources and want to report their experience through UMBC’s Title IX reporting process or police.
• We ask that you try to limit your story to about 3 minutes. We know it may be hard to do so but we want to make sure as many survivors as possible can speak during the allotted speak out time which is one hour long. If you’d like to continue sharing your story, you may want to go to the We Believe You discussion group after the Take Back the Night march.
• Speakers will have the option to identify their story as confidential by placing a sign marked “confidential” on the microphone. Speaking from the “confidential” microphone prohibits anyone from taking pictures, quotes, or recording of any kind.
• Counselors-On-Call will be available throughout the evening. Any one needing additional support or simply needs to take a break are invited to visit the self-care station that will be set up in the Commuter Lounge.

For more information about UMBC’s TBTN (check out Facebook, Instagram, and Twitter too by searching the hashtag #UMBCTBTN):

• Supporting Survivors of Sexual Violence Workshop information for students.
• Speak: Knowing a Survivor Without Knowing Their Story – a blog post on cultivating a survivor-responsive campus.
• The Women’s Center 2018 TBTN roundup
• The Retriever Weekly photo gallery of TBTN
• Stop by the Women’s Center on April 17th to make a rally sign for the march

• Graduate students to gain professional and interpersonal experience. Depending on your field, your time as a student may not open you up to many client-facing interactions, and this is a pathway to gaining that experience. If you are considering a career in academia, meanwhile, advising experience is highly sought-after in faculty openings.
• Part-time faculty to gain advising experience – highly sought-after in faculty openings – as well as to interact with students outside of the classroom. As an adjunct faculty member myself, I can absolutely say that my teaching effectiveness has been augmented by my advising experience.
• Full-time faculty and staff to begin to engage with your department’s incoming students at the earliest possible juncture: to give them the best possible head start in their studies (and to make your own future advising appointments easier!).
• Staff to engage in professional development in ways that may not be otherwise available – and then bring those skills back to your home department. Orientation advising requires and trains diverse skillsets, such as one-on-one academic advising and counseling, university-wide policies and protocols, inter-office collaboration, and much more!

What Effect Does a School University Partnership Have in Urban Baltimore City Public Schools?

Come see this poster presentation at 1-2:30pm in the UC Ballroom on Wednesday!

Hilary Grace Lahoury, Amber Brock
Mentor: Susan Sonnenschein, Psychology

Many children, in urban school systems, especially those from families of color or low-income households lack adequate learning opportunities (Anyon, 2014), which affects their academic progress and success. A school-university partnership which included the Literacy Fellows Program (volunteers) was implemented between Fall 2019 and Spring 2022 in two local schools to improve first and second graders’ literacy skills. We interviewed classroom teachers (N= 14) and undergraduate volunteers (N= 26) to examine the implementation and effectiveness of the program. We considered the nature of instruction, relations between the teacher and volunteer, and relations with the students in the class. Teachers and volunteers were highly positive about the program. Volunteers stated they enjoyed working with students on literacy tasks. Their assistance allowed the teachers to give much needed individualized attention to more students than when volunteers were not there. Volunteers also helped manage behavioral issues, formed meaningful relationships with the students with whom they worked, and served as role models for them. Teachers mentioned how they benefitted from an extra set of hands for students to receive extra individualized attention and to improve their reading skills. Among negative comments were insufficient training and difficulties maintaining relations with students during COVID-19.

See the full URCAD schedule at URCAD.umbc.edu

Come see Polina's presentation at URCAD this Wednesday!!

Location: 3:35pm in UC 204

Recovering from Hypoxia-Induced Metabolic Suppression: Role of NDRG1 in Na+/K+/ATPase Restoration to the Plasma Membrane

Polina Kassir
Mentor: Rachel Brewster, Biological Sciences

Oxygen’s critical role in ATP synthesis makes ischemia (lack of oxygen delivery) a potentially fatal injury. Zebrafish embryos, however, can survive nearly fifty hours in a zero-oxygen (anoxic) environment by entering a state of metabolic suppression characterized by metabolic arrest of ATP-demanding processes, such as ion pumping driven by the Na+-K+-ATPase (NKA). The Brewster Lab has previously shown that the N-myc Downstream Regulated Gene 1 (NDRG1) mediates NKA downregulation in the embryonic kidney and ionocytes; I demonstrated that this response is reversible and hence adaptive. Here, I explore the question of whether Ndrg1a promotes the return of membrane NKA levels upon re-oxygenation, using the proximity ligation assay (PLA) to detect whether these proteins interact in situ. My preliminary data reveal that the PLA signal intensifies in the anterior kidney and ionocytes with increasing time post re-oxygenation, which is consistent with a potential role for Ndrg1a as a versatile adapter protein and environmental oxygen sensor. Identification of the subcellular compartments where these proteins interact will further our understanding of the role of Ndrg1a in hypoxia adaptation. Overall, this research may lead to novel therapeutic approaches for the mitigation of hypoxic and reoxygenation injuries.

This work was funded, in part, by the Department of Defense and the National Institute of Health/NICHD.

For the full schedule of URCAD events, see: URCAD.umbc.edu