Structural Characterization of the HIV-1 MA-tRNA Complex
Graduate student research presentation
Wednesday, November 20, 2019 · Noon - 1 PM
The human immunodeficiency virus (HIV) remains a global health concern for which new therapies are required. Recent work reported that the HIV matrix protein interacts with cellular tRNAs, and biophysical studies demonstrated that the matrix-tRNA complex prevents subsequent interactions necessary to continue HIV replication. This project seeks to determine the 3D structure of the HIV matrix protein in complex with tRNA. Ultimately, better understanding this process of HIV biology may lend to the development of new HIV therapies.