The vision of this center is to advance AI-based autonomy in order to deliver safe, effective, and resilient new capabilities across a variety of complex mission types, including search-and-rescue, persistent surveillance, managing, adapting and optimizing smart, connected robots and machinery, and augmenting humans in performing complex analytical and decision-making tasks. These systems are continually getting better, but to achieve their potential, there are still numerous developments required to improve their capability, command and control, interoperability, resiliency and trustworthiness.