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<NewsItem contentIssues="true" id="41694" important="false" status="posted" url="https://my3.my.umbc.edu/posts/41694">
<Title>Bits Blog: At Mobile World Congress, a Sign of Tech Industry&#8217;s Shifting Focus</Title>
<Body>
<![CDATA[
    <div class="html-content">Mark Zuckerberg, the co-founder of Facebook, which started as a site designed for computers, will be a prominent speaker this week’s trade show revolving around mobile devices.<br><div><table border="0"><tbody><tr><td>
    <a href="http://share.feedsportal.com/share/twitter/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fat-mobile-world-congress-a-sign-of-tech-industrys-shifting-focus%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+At+Mobile+World+Congress%2C+a+Sign+of+Tech+Industry%E2%80%99s+Shifting+Focus" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/twitter.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/facebook/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fat-mobile-world-congress-a-sign-of-tech-industrys-shifting-focus%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+At+Mobile+World+Congress%2C+a+Sign+of+Tech+Industry%E2%80%99s+Shifting+Focus" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/facebook.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/linkedin/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fat-mobile-world-congress-a-sign-of-tech-industrys-shifting-focus%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+At+Mobile+World+Congress%2C+a+Sign+of+Tech+Industry%E2%80%99s+Shifting+Focus" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/linkedin.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/gplus/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fat-mobile-world-congress-a-sign-of-tech-industrys-shifting-focus%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+At+Mobile+World+Congress%2C+a+Sign+of+Tech+Industry%E2%80%99s+Shifting+Focus" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/googleplus.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/email/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fat-mobile-world-congress-a-sign-of-tech-industrys-shifting-focus%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+At+Mobile+World+Congress%2C+a+Sign+of+Tech+Industry%E2%80%99s+Shifting+Focus" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/email.png" style="max-width: 100%; height: auto;"></a>
    </td></tr></tbody></table></div>
    <br><br><a href="http://da.feedsportal.com/r/186531029300/u/0/f/640387/c/34625/s/3777a778/sc/15/rc/1/rc.htm" rel="nofollow external" class="bo"><img src="http://da.feedsportal.com/r/186531029300/u/0/f/640387/c/34625/s/3777a778/sc/15/rc/1/rc.img" style="max-width: 100%; height: auto;"></a><br><a href="http://da.feedsportal.com/r/186531029300/u/0/f/640387/c/34625/s/3777a778/sc/15/rc/2/rc.htm" rel="nofollow external" class="bo"><img src="http://da.feedsportal.com/r/186531029300/u/0/f/640387/c/34625/s/3777a778/sc/15/rc/2/rc.img" style="max-width: 100%; height: auto;"></a><br><a href="http://da.feedsportal.com/r/186531029300/u/0/f/640387/c/34625/s/3777a778/sc/15/rc/3/rc.htm" rel="nofollow external" class="bo"><img src="http://da.feedsportal.com/r/186531029300/u/0/f/640387/c/34625/s/3777a778/sc/15/rc/3/rc.img" style="max-width: 100%; height: auto;"></a><br><br><a href="http://da.feedsportal.com/r/186531029300/u/0/f/640387/c/34625/s/3777a778/a2.htm" rel="nofollow external" class="bo"><img src="http://da.feedsportal.com/r/186531029300/u/0/f/640387/c/34625/s/3777a778/a2.img" style="max-width: 100%; height: auto;"></a>
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</Body>
<Summary>Mark Zuckerberg, the co-founder of Facebook, which started as a site designed for computers, will be a prominent speaker this week’s trade show revolving around mobile devices.      </Summary>
<Website>http://bits.blogs.nytimes.com/2014/02/23/at-mobile-world-congress-a-sign-of-tech-industrys-shifting-focus/?partner=rss&amp;emc=rss</Website>
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<Tag>facebook-inc</Tag>
<Tag>mobile</Tag>
<Tag>mobile-world-congress</Tag>
<Tag>mobile-world-congress-trade-show</Tag>
<Tag>new</Tag>
<Tag>samsung-electronics-co</Tag>
<Tag>smartphones</Tag>
<Tag>technology</Tag>
<Tag>wearable-computing</Tag>
<Tag>york</Tag>
<Tag>zuckerberg-mark-e</Tag>
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<PostedAt>Sun, 23 Feb 2014 22:18:35 -0500</PostedAt>
<EditAt>Mon, 24 Feb 2014 08:24:22 -0500</EditAt>
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<NewsItem contentIssues="true" id="41680" important="false" status="posted" url="https://my3.my.umbc.edu/posts/41680">
<Title>The Stage to Wage a Raging Wage War</Title>
<Body>
<![CDATA[
    <div class="html-content">
    <p><a href="http://usdemocrazy.net/wp-content/uploads/2014/02/Real-Value-Minimum-Wage-NELP.jpg" rel="nofollow external" class="bo"><img alt="" src="http://usdemocrazy.net/wp-content/uploads/2014/02/Real-Value-Minimum-Wage-NELP.jpg" width="561" height="389" style="max-width: 100%; height: auto;"></a></p>
    <p>What’s the lowest you have been paid for a job? That low?</p>
    <p>If you’ve been following the political debate in Washington over the past year, or tuned into <a href="http://usdemocrazy.net/reboot-obama/" rel="nofollow external" class="bo">last month’s State of the Union address</a>, you probably heard something about the Democrats’ proposal to increase the federal minimum wage to $10.10/hr and index it to inflation.</p>
    <p>Sounds like a plan! Who wouldn’t want to get paid more?</p>
    <p>The problem is that there’s this pesky little thing in economics called <a href="http://en.wikipedia.org/wiki/Law_of_demand" rel="nofollow external" class="bo">the law of demand</a>. The law says that if something costs more, people tend to demand it less.</p>
    <p>So, all things being equal, raising the minimum wage should cause employers to demand fewer workers and unemployment to rise.</p>
    <p>This is what the Congressional Budget Office, a nonpartisan organization which analyzes economic and budgetary policy, concluded last week. They <a href="http://www.washingtonpost.com/business/economy/minimum-wage-hike-could-kill-500000-jobs-but-help-alleviate-poverty-cbo-reports/2014/02/18/d171c130-98de-11e3-80ac-63a8ba7f7942_story.html" rel="nofollow external" class="bo">estimated that raising the minimum wage to $10.10 could cost the economy around 500,000 jobs.</a></p>
    <p>To put that number in perspective, that’s equivalent to about <a href="http://www.bls.gov/news.release/pdf/empsit.pdf" rel="nofollow external" class="bo">4 months of job growth in 2013</a> being tossed out the window.</p>
    <p>Okay, never mind then! Bad plan!</p>
    <p>Perhaps. As is often the case in a system as large and complex as the US economy, all things are most certainly not equal.</p>
    <p>An employer could respond to a minimum wage increase <a href="http://www.washingtonpost.com/blogs/wonkblog/wp/2013/02/14/why-economists-are-so-puzzled-by-the-minimum-wage/" rel="nofollow external" class="bo">in a variety of different ways</a>. They might raise their prices or make efforts to improve workplace efficiency.</p>
    <p>And for some businesses, the benefits of a wage bump can offset some of the costs. Higher wages might result in better morale and worker productivity; they also allow businesses to save on recruitment and training costs, as employees are less likely to leave if they’re being paid more.</p>
    <p>As a result, it’s hard to say exactly how minimum wage hikes affect employment. <a href="http://blogs.wsj.com/economics/2014/01/30/should-the-minimum-wage-be-raised-economists-weigh-in/" rel="nofollow external" class="bo">Many economic studies of past wage hikes detected little-to-no rise in unemployment.</a></p>
    <p>But the CBO also found that a $10.10 wage would increase pay for 16.5 million workers (33 times the number of estimated job losses) and lift 900,000 of them over the poverty line. <a href="http://www.washingtonpost.com/blogs/wonkblog/wp/2014/01/04/economists-agree-raising-the-minimum-wage-reduces-poverty/" rel="nofollow external" class="bo">Economists find much more agreement on the potential benefits for the impoverished.</a></p>
    <p>Do you think we should raise the wage?</p>
    <p><a href="http://usdemocrazy.net/wp-content/uploads/2014/02/Kal-sun-2-9-14printB.jpg" rel="nofollow external" class="bo"><img alt="" src="http://usdemocrazy.net/wp-content/uploads/2014/02/Kal-sun-2-9-14printB-1024x748.jpg" width="553" height="404" style="max-width: 100%; height: auto;"></a></p>
    </div>
]]>
</Body>
<Summary>What’s the lowest you have been paid for a job? That low?   If you’ve been following the political debate in Washington over the past year, or tuned into last month’s State of the Union address,...</Summary>
<Website>http://usdemocrazy.net/the-stage-to-wage-a-raging-wage-war/</Website>
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<Tag>democracy</Tag>
<Tag>economics</Tag>
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<Tag>politics</Tag>
<Tag>poverty</Tag>
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<Tag>what-the-heconomics</Tag>
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<PostedAt>Sun, 23 Feb 2014 22:08:01 -0500</PostedAt>
<EditAt>Sun, 23 Feb 2014 22:58:01 -0500</EditAt>
</NewsItem>

<NewsItem contentIssues="true" id="41681" important="false" status="posted" url="https://my3.my.umbc.edu/posts/41681">
<Title>Yahoo Aims to More Deftly Blend Ads With Content</Title>
<Body>
<![CDATA[
    <div class="html-content">Yahoo is starting to push into two of the hottest areas of Internet advertising: stream ads and so-called native ads.<br><div><table border="0"><tbody><tr><td>
    <a href="http://share.feedsportal.com/share/twitter/?u=http%3A%2F%2Fwww.nytimes.com%2F2014%2F02%2F24%2Ftechnology%2Fyahoo-aims-to-more-deftly-blend-ads-with-content.html%3Fpartner%3Drss%26emc%3Drss&amp;t=Yahoo+Aims+to+More+Deftly+Blend+Ads+With+Content" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/twitter.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/facebook/?u=http%3A%2F%2Fwww.nytimes.com%2F2014%2F02%2F24%2Ftechnology%2Fyahoo-aims-to-more-deftly-blend-ads-with-content.html%3Fpartner%3Drss%26emc%3Drss&amp;t=Yahoo+Aims+to+More+Deftly+Blend+Ads+With+Content" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/facebook.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/linkedin/?u=http%3A%2F%2Fwww.nytimes.com%2F2014%2F02%2F24%2Ftechnology%2Fyahoo-aims-to-more-deftly-blend-ads-with-content.html%3Fpartner%3Drss%26emc%3Drss&amp;t=Yahoo+Aims+to+More+Deftly+Blend+Ads+With+Content" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/linkedin.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/gplus/?u=http%3A%2F%2Fwww.nytimes.com%2F2014%2F02%2F24%2Ftechnology%2Fyahoo-aims-to-more-deftly-blend-ads-with-content.html%3Fpartner%3Drss%26emc%3Drss&amp;t=Yahoo+Aims+to+More+Deftly+Blend+Ads+With+Content" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/googleplus.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/email/?u=http%3A%2F%2Fwww.nytimes.com%2F2014%2F02%2F24%2Ftechnology%2Fyahoo-aims-to-more-deftly-blend-ads-with-content.html%3Fpartner%3Drss%26emc%3Drss&amp;t=Yahoo+Aims+to+More+Deftly+Blend+Ads+With+Content" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/email.png" style="max-width: 100%; height: auto;"></a>
    </td></tr></tbody></table></div>
    <br><br><a href="http://da.feedsportal.com/r/186531000901/u/0/f/640387/c/34625/s/3772f675/sc/4/rc/1/rc.htm" rel="nofollow external" class="bo"><img src="http://da.feedsportal.com/r/186531000901/u/0/f/640387/c/34625/s/3772f675/sc/4/rc/1/rc.img" style="max-width: 100%; height: auto;"></a><br><a href="http://da.feedsportal.com/r/186531000901/u/0/f/640387/c/34625/s/3772f675/sc/4/rc/2/rc.htm" rel="nofollow external" class="bo"><img src="http://da.feedsportal.com/r/186531000901/u/0/f/640387/c/34625/s/3772f675/sc/4/rc/2/rc.img" style="max-width: 100%; height: auto;"></a><br><a href="http://da.feedsportal.com/r/186531000901/u/0/f/640387/c/34625/s/3772f675/sc/4/rc/3/rc.htm" rel="nofollow external" class="bo"><img src="http://da.feedsportal.com/r/186531000901/u/0/f/640387/c/34625/s/3772f675/sc/4/rc/3/rc.img" style="max-width: 100%; height: auto;"></a><br><br><a href="http://da.feedsportal.com/r/186531000901/u/0/f/640387/c/34625/s/3772f675/a2.htm" rel="nofollow external" class="bo"><img src="http://da.feedsportal.com/r/186531000901/u/0/f/640387/c/34625/s/3772f675/a2.img" style="max-width: 100%; height: auto;"></a>
    </div>
]]>
</Body>
<Summary>Yahoo is starting to push into two of the hottest areas of Internet advertising: stream ads and so-called native ads.      </Summary>
<Website>http://www.nytimes.com/2014/02/24/technology/yahoo-aims-to-more-deftly-blend-ads-with-content.html?partner=rss&amp;emc=rss</Website>
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<Tag>advertising-and-marketing</Tag>
<Tag>coca-cola-company-ko-nyse</Tag>
<Tag>facebook-inc-fb-nasdaq</Tag>
<Tag>google-inc-goog-nasdaq</Tag>
<Tag>intel-corporation-intc-nasdaq</Tag>
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<Tag>mcdonalds-corporation-mcd-nyse</Tag>
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<Tag>new</Tag>
<Tag>online-advertising</Tag>
<Tag>pepsico-inc-pep-nyse</Tag>
<Tag>technology</Tag>
<Tag>twitter-twtr-nyse</Tag>
<Tag>unilever-nv-un-nyse</Tag>
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<PostedAt>Sun, 23 Feb 2014 21:58:15 -0500</PostedAt>
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<NewsItem contentIssues="true" id="41685" important="false" status="posted" url="https://my3.my.umbc.edu/posts/41685">
<Title>Seeking a Lead on News, Network Turns to Data-Mining Media Group</Title>
<Body>
<![CDATA[
    <div class="html-content">News organizations are rushing to form alliances with new companies they hope can give them an edge in finding stories and attracting younger viewers.<br><div><table border="0"><tbody><tr><td>
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</Body>
<Summary>News organizations are rushing to form alliances with new companies they hope can give them an edge in finding stories and attracting younger viewers.      </Summary>
<Website>http://www.nytimes.com/2014/02/24/business/media/teaming-with-data-mining-security-firms-to-get-a-lead-on-news.html?partner=rss&amp;emc=rss</Website>
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<Tag>google-inc-goog-nasdaq</Tag>
<Tag>msnbc</Tag>
<Tag>new</Tag>
<Tag>news-and-news-media</Tag>
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<Tag>television</Tag>
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<Tag>vocativ</Tag>
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<PostedAt>Sun, 23 Feb 2014 21:07:49 -0500</PostedAt>
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</NewsItem>

<NewsItem contentIssues="true" id="41695" important="false" status="posted" url="https://my3.my.umbc.edu/posts/41695">
<Title>Bits Blog: New Version of Two-Faced YotaPhone to Have Larger Screens and More Power</Title>
<Body>
<![CDATA[
    <div class="html-content">The next generation YotaPhone builds on the ideas of the first edition, in a thinner unibody shape with curved edges.<br><div><table border="0"><tbody><tr><td>
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]]>
</Body>
<Summary>The next generation YotaPhone builds on the ideas of the first edition, in a thinner unibody shape with curved edges.      </Summary>
<Website>http://bits.blogs.nytimes.com/2014/02/23/new-version-of-two-faced-yotaphone-to-have-larger-screens-and-more-power/?partner=rss&amp;emc=rss</Website>
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<Tag>mobile</Tag>
<Tag>mobile-world-congress</Tag>
<Tag>new</Tag>
<Tag>smartphones</Tag>
<Tag>technology</Tag>
<Tag>york</Tag>
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<PostedAt>Sun, 23 Feb 2014 21:00:51 -0500</PostedAt>
<EditAt>Mon, 24 Feb 2014 08:01:32 -0500</EditAt>
</NewsItem>

<NewsItem contentIssues="true" id="41678" important="false" status="posted" url="https://my3.my.umbc.edu/posts/41678">
<Title>Comcast and Netflix Reach Deal on Service</Title>
<Body>
<![CDATA[
    <div class="html-content">Comcast and Netflix announced an agreement Sunday in which Netflix will pay Comcast for faster and more reliable access to Comcast’s subscribers.<br><div><table border="0"><tbody><tr><td>
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    </div>
]]>
</Body>
<Summary>Comcast and Netflix announced an agreement Sunday in which Netflix will pay Comcast for faster and more reliable access to Comcast’s subscribers.      </Summary>
<Website>http://www.nytimes.com/2014/02/24/business/media/comcast-and-netflix-reach-a-streaming-agreement.html?partner=rss&amp;emc=rss</Website>
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<Tag>computers-and-the-internet</Tag>
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<PostedAt>Sun, 23 Feb 2014 16:40:26 -0500</PostedAt>
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</NewsItem>

<NewsItem contentIssues="true" id="41696" important="false" status="posted" url="https://my3.my.umbc.edu/posts/41696">
<Title>Bits Blog: Q.&amp;A. With Joe Belfiore on the Future of Windows Phone</Title>
<Body>
<![CDATA[
    <div class="html-content">Joe Belfiore, the corporate vice president of Microsoft Windows Phone, discusses goals for 2014 and the potential upside of the company’s Nokia deal.<br><div><table border="0"><tbody><tr><td>
    <a href="http://share.feedsportal.com/share/twitter/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fq-a-with-joe-belfiore-on-the-future-of-windows-phone%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+Q.%26A.+With+Joe+Belfiore+on+the+Future+of+Windows+Phone" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/twitter.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/facebook/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fq-a-with-joe-belfiore-on-the-future-of-windows-phone%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+Q.%26A.+With+Joe+Belfiore+on+the+Future+of+Windows+Phone" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/facebook.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/linkedin/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fq-a-with-joe-belfiore-on-the-future-of-windows-phone%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+Q.%26A.+With+Joe+Belfiore+on+the+Future+of+Windows+Phone" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/linkedin.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/gplus/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fq-a-with-joe-belfiore-on-the-future-of-windows-phone%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+Q.%26A.+With+Joe+Belfiore+on+the+Future+of+Windows+Phone" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/googleplus.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/email/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fq-a-with-joe-belfiore-on-the-future-of-windows-phone%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+Q.%26A.+With+Joe+Belfiore+on+the+Future+of+Windows+Phone" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/email.png" style="max-width: 100%; height: auto;"></a>
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</Body>
<Summary>Joe Belfiore, the corporate vice president of Microsoft Windows Phone, discusses goals for 2014 and the potential upside of the company’s Nokia deal.      </Summary>
<Website>http://bits.blogs.nytimes.com/2014/02/23/q-a-with-joe-belfiore-on-the-future-of-windows-phone/?partner=rss&amp;emc=rss</Website>
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<Tag>cellular-telephones</Tag>
<Tag>joe-belfiore</Tag>
<Tag>microsoft-corporation</Tag>
<Tag>microsoft-corporation-msft-nasdaq</Tag>
<Tag>mobile</Tag>
<Tag>mobile-world-congress</Tag>
<Tag>new</Tag>
<Tag>nokia-oyj</Tag>
<Tag>nokia-oyj-nok-nyse</Tag>
<Tag>one-on-one</Tag>
<Tag>smartphones</Tag>
<Tag>technology</Tag>
<Tag>york</Tag>
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<PostedAt>Sun, 23 Feb 2014 14:44:32 -0500</PostedAt>
<EditAt>Mon, 24 Feb 2014 10:55:05 -0500</EditAt>
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<NewsItem contentIssues="false" id="41674" important="false" status="posted" url="https://my3.my.umbc.edu/posts/41674">
<Title>Lindahl Lab: Little Changes Wreak Big Havoc</Title>
<Tagline>Examining role of phosphorylation site on ribosomal protein</Tagline>
<Body>
<![CDATA[
    <div class="html-content">
    <strong>Little Changes Wreak Big Havoc:<br>Lindahl lab examines role of phosphorylation site on ribosomal protein </strong><br><br>By Sarah Hansen<br><br>Yeast ribosome structure image: <a href="https://pubs.acs.org/cen/news/88/i48/8848notw1.html">https://pubs.acs.org/cen/news/88/i48/8848notw1.html</a><br><br>Modifying the molecular composition of a specific protein can prevent construction of functional ribosomes, key components of all cells. Graduate student <a href="http://www.umbc.edu/Programs/Meyerhoff/graduate/JesseFox.htm" rel="nofollow external" class="bo">Jesse Fox</a> and other members of <a href="http://biology.umbc.edu/directory/faculty/lindahl/" rel="nofollow external" class="bo">Dr. Lasse Lindahl</a>’s lab at UMBC are seeking to elucidate minutiae of the structure and function of these busy cell structures.  <br><br>Lindahl has been studying ribosomes for almost 50 years – but there’s still a lot to learn, he says.  Lindahl notes “50 percent of a cell’s resources are devoted to ribosomes, even more in fast growing cells.”  That makes it especially important to understand their inner workings.<br><br>Ribosomes serve as cellular factories, churning out proteins by translating messenger RNAs into chains of amino acid building blocks.  These chains, called “polypeptides”, fold up to become full-fledged proteins with distinct 3D shapes.  A protein’s shape determines its function.<br>  <br>Without properly-formed ribosomes, our bodies couldn’t produce the proteins we need to build bones, muscles, and brain tissue, nor could we create enzymes (a class of proteins) to carry out chemical reactions.  Importantly, ribosomes with just slight modifications in their structure have been linked to skeletal abnormalities, severe anemia, immune system problems and eye problems. <br><br>Fox uses yeast (Saccharomyces cerevisiae) to study the complicated process of ribosome construction.  Every yeast ribosome consists of two subunits: the large “60S” subunit and the small “40S” subunit.  Each of these is made out of ribosomal RNA (rRNA) and protein.   Get this: the large subunit contains 3 rRNAs and 47 proteins, and the small subunit has 1 rRNA and 32 proteins.  That means each ribosome has 83 separate parts that need to be combined in just the right way to fulfill its function.  Plus, there are at least 200 “assembly factors” that help the ribosome get put together just so.  Clearly, this piece of cellular machinery has a lot going on – and a lot of steps where something could go wrong.<br><br>So how did a baking ingredient become a study organism?  Yeast is a single-celled fungus.  It is easy to manipulate in the lab, and scientists have mapped its entire genome.  Developmentally, yeast is also one of the simplest eukaryotes.  Humans are eukaryotic, too, which means we have a lot in common with yeast at a basic cellular level, including ribosome function.  <br><br>Fox’s work focuses on the L4 protein, one of the proteins in the large ribosomal subunit.  He studies its phosphorylation sites.  Phosphorylation is the process by which a phosphate group (four oxygen atoms and one phosphorus atom) is covalently bonded to an amino acid in the protein.  Phosphorylation is important: mis-regulation of phosphorylation in other proteins has been linked to Alzheimer’s, Parkinson’s, and cancer. <br><br>The L4 protein contains 15 of the 300 phosphorylation sites in the yeast ribosome, making it the most-phosphorylated ribosomal protein.  Four of these fifteen sites are conserved between yeast and humans, which means human L4 proteins are also phosphorylated at those four locations.  All this makes L4 a great choice for studying the effects of phosphorylation on ribosome function. <br><br>One of Fox’s primary questions is why L4 is so heavily phosphorylated. He hypothesizes that phosphorylation “provid[es] checkpoints during the synthesis process,” making sure the ribosome is ready “before it can go on to the next step.”    <br><br>Phosphorylation may also help materials travel to and from the cell nucleus.  A third possibility is that “all 300 phosphorylated sites on the ribosome could work together to change how fast it translates mRNA into protein,” Fox said.<br>As Fox analyzed the L4 phosphorylation sites, he found one site in particular that, when altered, resulted in a different growth pattern in the yeast cells.  The amino acid at position 129 in the primary sequence seemed critical.<br>  <br>To investigate the effects of phophorylation at this site, Fox used genetic <br>engineering techniques to replace amino acid 129 (normally threonine) with two different amino acids (either alanine or glutamic acid).  Then he looked at how these small changes – just 1 amino acid out of 256 in the L4 protein – affected cell growth.  Cells with the alanine replacement grew normally, but the cells with glutamic acid in the same position didn’t grow at all.  <br><br>This result was noteworthy, because glutamic acid is actually more similar to a phosphorylated threonine than is alanine.  The result points to how the dynamic addition and removal of phosphate groups on threonine plays a role in successful cell growth – acting phosphorylated all the time, as glutamic acid does, doesn’t cut it.    <br><br>Fox also wanted to know if L4 phosphorylation state affects the ability of the cell to build the ribosome subunits correctly. He conducted northern blot analysis, which identifies the relative concentrations of certain RNA sequences in a sample, on three different yeast strains.  The only difference between the strains was the amino acid at position 129: threonine, alanine, or glutamic acid.  <br><br>The results revealed differences among the three strains in the presence of pre-ribosomal RNA, rRNA that after some molecular “editing” would be used to build a ribosome.  Because the only difference between the strains was the one mutation, any differences in rRNA synthesis could be attributed to that.  Sure enough, the strain with the glutamic acid mutation produced mis-edited rRNA.  Fox concluded that phosphorylation state at position 129 in L4 plays a role in regulating rRNA synthesis, and therefore, ribosome construction.  The question that still remains: how?     <br><br>“We need to confirm the results in multiple ways,” Fox says.  <br>Fox plans to look at the molecules that are made in the process of building ribosomes – “precursor” molecules – in cells with the glutamic acid mutation.  If precursors are present prior to a certain step in synthesis, but then the next molecule in the sequence is absent, that will be strong evidence for synthesis breaking down at that step.  He hopes this experiment will corroborate his results from the Northern blots. <br> <br>He also wants to identify the location within the cell of proteins with the glutamic acid mutation.  “Determining the mutant protein’s location will help us determine if the protein is being effectively transported into the nucleus, where it is assembled onto the ribosome,” he says.    <br><br>Learning about one site, on one protein, in one cell structure, may seem like small potatoes to an outsider. But painstaking research like Fox’s will increase understanding of ribosome function and may ultimately lead to cures for debilitating conditions.  <br><br>If you have any questions about his research, contact Mr. Fox at <a href="mailto:foxj1@umbc.edu">foxj1@umbc.edu</a>.  <br><br>
    </div>
]]>
</Body>
<Summary>Little Changes Wreak Big Havoc: Lindahl lab examines role of phosphorylation site on ribosomal protein   By Sarah Hansen  Yeast ribosome structure image:...</Summary>
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<PostedAt>Sun, 23 Feb 2014 12:18:12 -0500</PostedAt>
<EditAt>Fri, 28 Mar 2014 18:20:51 -0400</EditAt>
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<NewsItem contentIssues="true" id="41675" important="false" status="posted" url="https://my3.my.umbc.edu/posts/41675">
<Title>Bits Blog: Samsung Introduces Two New Smartwatches</Title>
<Body>
<![CDATA[
    <div class="html-content">The devices have a better battery life and use Samsung’s own operating system.<br><div><table border="0"><tbody><tr><td>
    <a href="http://share.feedsportal.com/share/twitter/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fsamsung-introduces-two-new-smart-watches%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+Samsung+Introduces+Two+New+Smartwatches" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/twitter.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/facebook/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fsamsung-introduces-two-new-smart-watches%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+Samsung+Introduces+Two+New+Smartwatches" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/facebook.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/linkedin/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fsamsung-introduces-two-new-smart-watches%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+Samsung+Introduces+Two+New+Smartwatches" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/linkedin.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/gplus/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fsamsung-introduces-two-new-smart-watches%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+Samsung+Introduces+Two+New+Smartwatches" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/googleplus.png" style="max-width: 100%; height: auto;"></a> <a href="http://share.feedsportal.com/share/email/?u=http%3A%2F%2Fbits.blogs.nytimes.com%2F2014%2F02%2F23%2Fsamsung-introduces-two-new-smart-watches%2F%3Fpartner%3Drss%26emc%3Drss&amp;t=Bits+Blog%3A+Samsung+Introduces+Two+New+Smartwatches" rel="nofollow external" class="bo"><img src="http://res3.feedsportal.com/social/email.png" style="max-width: 100%; height: auto;"></a>
    </td></tr></tbody></table></div>
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    </div>
]]>
</Body>
<Summary>The devices have a better battery life and use Samsung’s own operating system.      </Summary>
<Website>http://bits.blogs.nytimes.com/2014/02/23/samsung-introduces-two-new-smart-watches/?partner=rss&amp;emc=rss</Website>
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<Tag>devices</Tag>
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<Tag>watches-and-clocks</Tag>
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<PostedAt>Sun, 23 Feb 2014 12:04:51 -0500</PostedAt>
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<NewsItem contentIssues="true" id="41676" important="false" status="posted" url="https://my3.my.umbc.edu/posts/41676">
<Title>Disruptions: After WhatsApp Deal, Visions of Magic Numbers</Title>
<Body>
<![CDATA[
    <div class="html-content">How much money would it take for you to sell your start-up, quit your job or close your venture capital fund and walk away from it all?<br><div><table border="0"><tbody><tr><td>
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<Summary>How much money would it take for you to sell your start-up, quit your job or close your venture capital fund and walk away from it all?      </Summary>
<Website>http://bits.blogs.nytimes.com/2014/02/23/disruptions-after-whatsapp-deal-visions-of-magic-numbers/?partner=rss&amp;emc=rss</Website>
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<Tag>mobile</Tag>
<Tag>new</Tag>
<Tag>silicon-valley-calif</Tag>
<Tag>social</Tag>
<Tag>start-ups</Tag>
<Tag>technology</Tag>
<Tag>whatsapp-inc</Tag>
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<PostedAt>Sun, 23 Feb 2014 12:00:59 -0500</PostedAt>
<EditAt>Mon, 24 Feb 2014 14:55:03 -0500</EditAt>
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