D.C. Bar membership is not required to attend. Non-members will need to create a profile to register. 

This remote series will be hosted on the Zoom platform. You will receive access information from D.C. Bar Communities staff the afternoon prior to the program. The Zoom access information should not be shared with other, as registration is required. 

Sponsored by:  D.C. Bar Law Student Community

Related Communities of Interest:  D.C. Bar Early Career Lawyers Community; D.C. Bar Public Interest and Court Community

Program Partner: D.C. Lawyers Chapter of the American Constitution Society

Please make sure to read all the eligibility requirements and position descriptions in the form. Let us know if you have any other questions or concerns! 

Advisor: Dr. Liang Zhu

Title: Evaluating microcracks in enhancing nanofluid flow from capillaries to the interstitial space in tumor core regions – theoretical simulations

Abstract:

Limited drug delivery outcomes using systemic delivery are attributed to tumor microenvironment. The objective of this study is to investigate the effect of introduction of microcracks in tumors on tumoral IFP reduction to facilitate therapeutic agent delivery to tumors. We developed a theoretical model for fluid transport in a spherical tumor incorporating Starling’s law and Darcy’s law. Results have shown that introduction of 4 microcracks in tumors is effective to lower the maximal IFP in the tumor from 1941 Pa to 1722.1 Pa, by up to 11.3%.  Although the reduction of the average IFP in the entire tumor is limited, it is evident that this approach is effective to decrease the average IFP in the tumor core regions with up to 16.8% reduction from the baseline case without microcrack. We conclude that introducing several microcracks in tumors is an effective method to facilitate transcapillary fluid/drug flow to tumor interstitial fluid space.

Paris Graduate School of East Asian Studies, Université Paris Cité