Ladew Topiary Gardens (Ladew) seeks an Associate, Annual Fund and Membership to continue building on the fundraising program’s success in recent years. Reporting to the Senior Director, Development and Communications, and working closely with the Director of Development, the Associate, Annual Fund and Membership will nurture positive relationships with all constituencies, including current and prospective donors of less than $1,500 annually, current and prospective members, other friends of Ladew Gardens, and a collegial staff.

Welcome to our latest podcast episode, where we sit down with Samantha Novak, a UMBC graduate faculty member, to discuss leading with emergent strategies. In this thought-provoking conversation, Ms. Novak shares her insights on the importance of reflecting on our work in the world and how we choose to show up to it. 

We delve into the idea that real transformative change can only occur if we have first worked on making sustainable changes within ourselves. She offers valuable insights on how we can approach this process and highlights the key role that self-awareness plays in leadership.

Throughout the episode, we explore different examples of how emergent strategies can be applied in different contexts and discuss the challenges that come with leading in an ever-changing world.

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Come see Polina's presentation at URCAD this Wednesday!!

Location: 3:35pm in UC 204

Recovering from Hypoxia-Induced Metabolic Suppression: Role of NDRG1 in Na+/K+/ATPase Restoration to the Plasma Membrane

Polina Kassir
Mentor: Rachel Brewster, Biological Sciences

Oxygen’s critical role in ATP synthesis makes ischemia (lack of oxygen delivery) a potentially fatal injury. Zebrafish embryos, however, can survive nearly fifty hours in a zero-oxygen (anoxic) environment by entering a state of metabolic suppression characterized by metabolic arrest of ATP-demanding processes, such as ion pumping driven by the Na+-K+-ATPase (NKA). The Brewster Lab has previously shown that the N-myc Downstream Regulated Gene 1 (NDRG1) mediates NKA downregulation in the embryonic kidney and ionocytes; I demonstrated that this response is reversible and hence adaptive. Here, I explore the question of whether Ndrg1a promotes the return of membrane NKA levels upon re-oxygenation, using the proximity ligation assay (PLA) to detect whether these proteins interact in situ. My preliminary data reveal that the PLA signal intensifies in the anterior kidney and ionocytes with increasing time post re-oxygenation, which is consistent with a potential role for Ndrg1a as a versatile adapter protein and environmental oxygen sensor. Identification of the subcellular compartments where these proteins interact will further our understanding of the role of Ndrg1a in hypoxia adaptation. Overall, this research may lead to novel therapeutic approaches for the mitigation of hypoxic and reoxygenation injuries.

This work was funded, in part, by the Department of Defense and the National Institute of Health/NICHD.

For the full schedule of URCAD events, see: URCAD.umbc.edu