UMBC CSEE professors Konstantinos Kalpakis and Dong Li received research funding from the University of Maryland, Baltimore’s Institute for Clinical and Translational Research to collaborate with UMB partners to develop innovative healthcare technology.

Professor Kalpakis and his colleagues are developing a new approach to help trauma physicians make better-informed treatment decisions quickly. The team is working on a machine-learning framework that can help ER doctors predict medical outcomes, such as which patients will experience severe complications from trauma and what their blood transfusion needs may be.

Professor Li's work will use AI technology to develop a reliable method to monitor blood pressure on a smartphone outfitted with ultrasound sensors to measure blood flow and using the built-in microphone to record heart sounds. The partnership with UMB will allow the team to conduct clinical trials, with both healthy individuals and those with hypertension, to rigorously evaluate the system’s accuracy and effectiveness.

Imagine cells navigating through a complex maze, guided by chemical signals and the physical landscape of their environment. At UMBC, a team of researchers has contributed an important discovery about how cells move, or migrate, through this maze of bodily tissues. Potential implications include better understanding of diseases like cancer and advancing medical treatments. 

Published in iScience, the team’s study combines biological experiments and mathematics to reveal new insights into cell migration. Alex George, Ph.D. ’24, biological sciences, and Naghmeh Akhavan, Ph.D. ’25, mathematics, led the study, which explores how cells in fruit fly egg chambers navigate their environment. Their mentors, Michelle Starz-Gaiano, professor of biological sciences, and Brad Peercy, professor of mathematics, are co-authors. 

By integrating mathematical modeling with advanced imaging, the team discovered that the physical shape of the egg chamber, combined with chemical signals called chemoattractants, significantly influences how cells move. 

“This paper takes an interdisciplinary focus with tight collaboration between a mathematical framework and experimental design,” Peercy says. “The results promote the idea that complex distribution of chemical attractants can explain specific variations in migratory movement.” His enthusiasm highlights the study’s innovative approach, which merges precise mathematical models with real-world biological experiments to uncover patterns that were previously invisible.

Following the breadcrumbs

The team’s work focuses on border cells, a type of cell in fruit fly egg chambers, which are a model system for studying cell migration because of their similarities to processes in human development and disease. The team found that the border cells’ movement wasn’t just driven by continuously increasing chemical concentrations from one end of the egg chamber to the other, as earlier models suggested. Instead, the physical structure of the tissue—narrow tubes alternating with wider gaps—played a critical role. 

“This was the first time that we characterized that there were these patterns of migration behavior that ended up correlating to aspects of the tissue geometry,” explains George, who specializes in capturing live images of these cells. He likens the process to Hansel and Gretel following breadcrumbs through a forest: On a flat plain, the trail is clear, but in a landscape with ravines and valleys, the breadcrumbs pool in unexpected ways, complicating the path.

To understand this, Akhavan developed mathematical models that simulate how cells respond to both chemical signals and tissue geometry together. “Alex’s experiments showed that the speed is not exactly the way previous models showed it,” she says. Her models revealed that cells speed up in narrow tubes and slow down in larger gaps, a pattern confirmed by George’s imaging. 

Both approaches—wet-lab experiments and modeling—bring unique strengths to the work. Putting them together “is like unveiling the invisible from two different perspectives,” George says. “My experiments would refine her model, and her model would refine my experiments.”

And then, “When our model shows exactly what Alex found in his experiments, we love that,” Akhavan adds.

Learning new languages

This synergy didn’t always come easily. Working across disciplines meant learning to speak each other’s scientific “languages.” Akhavan, with a background in pure mathematics, recalls that when she joined the project in spring 2022, “Everything was in a different language for me.” Similarly, “A couple of times I opened my MATLAB code and Alex’s eyes got huge,” Akhavan laughs. 

Yet, their collaboration flourished, fostering not only scientific breakthroughs but also friendship. “It’s a challenge to communicate across disciplines since it’s almost like speaking in different languages,” Starz-Gaiano says. “Both Alex and Naghmeh got more adept at explaining their work and honing their research questions as a result of working together over a couple of years, which was great to watch.”

Putting together wet lab experiments and mathematical modeling “is like unveiling the invisible from two different perspectives. My experiments would refine her model, and her model would refine my experiments.”

Alex George, Ph.D. ’24, biological sciences

“It is a risky and vulnerable situation to be open with colleagues in areas in which you are not a burgeoning expert,” Peercy adds. “Naghmeh and Alex have grown so much through this project to genuinely rely on each other’s opinion.”

The study’s broader impact lies in its potential to inform fields beyond developmental biology. Cell migration is critical in processes like wound healing, immune responses, and cancer metastasis. “Most research on how cells navigate the world has focused only on chemical signals or only on structural ones, so this is one of the first studies to consider how those two things impact each other, which is likely to be relevant in many cases,” Starz-Gaiano explains. By showing how tissue geometry and chemical signals interact, the research could guide new strategies for controlling cell movement via medical treatments.

New strategies lead to new discoveries

George refined his expertise in microscopy through working with Tagide deCarvalho in UMBC’s Keith R. Porter Imaging Facility. “It helped me learn a lot, getting my hands on other people’s work and visualizing all the cool things,” he says. “A picture is worth a thousand words, but a movie? Ten thousand words.” Now he’s taking his skills to the Dartmouth Cancer Center’s microscopy core facility at the Geisel School of Medicine, where he’ll start as a research scientist in June.

For Akhavan and George, leading this project has been a defining experience. Akhavan’s models, including a new approach that uses energy calculations to better capture the egg chamber’s complex geometry, have become a cornerstone of her dissertation, and she plans to continue this work post-graduation. 

George and Akhavan’s mentors played a pivotal role in their success. “Michelle is a role model for me,” Akhavan says, praising the collaborative spirit of Starz-Gaiano and Peercy. “Dr. Peercy and Dr. Starz-Gaiano make the best combination for doing interdisciplinary research. This collaboration is amazing.” 

The team’s work continues to evolve, including recent experiments at the Advanced Imaging Center at the Janelia Research Campus in Virginia, where George used advanced microscopes to capture previously unseen dynamics of the relevant chemoattractants. These findings will further refine their models, opening new avenues for research. 

“We are developing new experimental strategies both on the biology and the math side of things,” Starz-Gaiano says, “so it will be exciting to see where this will take us next.”

For Rachel Brewster, professor of biological sciences, “science has always been visual,” she says. Her laboratory focuses on developmental biology, using zebrafish as a model organism. Zebrafish have transparent embryos, and imaging them as they grow and change is a core element of her group’s data collection. 

“There is endless complexity and beauty captured in the images we generate using increasingly advanced imaging technologies,” Brewster says. “To me, this is not unlike the experience of viewing great works of art, such as impressionist paintings that bring the natural world to life through color, texture, and contrast.” 

To that end, Brewster endowed the new Havelock and Jennifer Brewster Art of Science award in the College of Natural and Mathematical Sciences (CNMS). The award recognizes one CNMS student per year who produces original, visually stunning photographs, illustrations, or data visualizations that effectively communicate an important aspect of research.

“Scientific imaging that captures both beauty and meaning takes time, skill, and perseverance,” Brewster says. The new award acknowledges that “this kind of work deserves recognition not just within the scientific community, but beyond, because it has the power to spark curiosity, inspire others, and make science more accessible and engaging to the wider public.”

Opening people’s minds to the art of science

Maggie Wang, a junior biochemistry and molecular biology major with a minor in art history and museum studies, is the first recipient of the new award. Participating in UMBC’s SCIART program, a collaboration with the Walters Art Museum in Baltimore, initially “opened my mind to the intersection of science and art,” Wang says. 

As an undergraduate researcher in UMBC’s Molecular Characterization and Analysis Complex (MCAC), Wang’s desire to better understand the research equipment in the MCAC led her to produce detailed illustrations explaining the purpose of various instruments and the techniques they employ. With the encouragement of Cynthia Tope Niedermaier,MCAC facility manager, Wang polished her illustrations to help others learn about the equipment.

This summer, Wang will develop educational diagrams of more MCAC instruments. In addition to her scientific art, she works with graphite, ink, and yarn to create pieces that frequently focus on themes of Chinese culture and women’s fashion. Wang plans to pursue additional study in medical illustration after she graduates from UMBC. 

“Making art is a cathartic experience that allows me to express my creativity and emotions,” Wang says. “It also helps me connect with people from different backgrounds, opening the door to new perspectives and meaningful connections.”

Giving back in gratitude

Brewster strongly believes in UMBC’s mission to bring together and support students from a wide range of backgrounds, a goal she lives out daily within her own research group. Recently she also became co-lead of UMBC’s Meyerhoff Graduate Fellows Program, which offers financial support and a close community feel to promising STEM students from all backgrounds. 

“I have seen firsthand the powerful role the program plays in building the next generation of scientists,” Brewster says. “The Meyerhoff Program offers a proven framework, showing that by engaging all those who have something to contribute, we can continue to thrive as a nation.”

Brewster’s gift to fund this award is also “a small expression of my deep and lasting gratitude to my late parents, whom I love and miss every day,” she says. UMBC has also had a major role in shaping her identity. “UMBC has been my home since 2004. It is here that I have grown, not just as a scientist, but as a person. A big part of who I am is inextricably linked to this university.”

This is regarding the annually scheduled High-Temperature Hot Water (HTHW) system shutdown that will affect multiple buildings across campus. The HTHW system affects heat, air conditioning and domestic hot water at sinks, showers, etc. The shutdown will begin Friday, May 23 and conclude by Monday, June 9, 2025, and is part of a major infrastructure maintenance and repair to improve reliability and system performance.

Full List of Impacted Buildings:

    - Chemistry Building, HHMI (Howard Hughes Medical Institute)

    - Physics Building

    - Erickson Hall

    - Performing Arts & Humanities Building (PAHB)

    - Interdisciplinary Life Sciences Building (ILSB)

    - Engineering & Computing Services (ECS)

    - Information Technology & Engineering (ITE)

    - Library (to include Special Collections)

    - Sondheim Hall

    - Administration Building

    - Commons

    - RAC

    - Biology/Schwartz

    - UC

    - Sherman

    - Math/Psych

    - Public Policy

    - Fine Arts

    - Central Plant/Police Station

Anticipated Impacts:

Domestic Hot Water Availability:

·         The food service venues at The Commons and Chick-fil-A will continue to have domestic hot water via stand-by electric water heaters. True Grits Dining Hall is not affected.

·         RAC locker room bathrooms near the pool will have domestic hot water via stand-by electric water heaters. The pools will not be heated.

·         Other locations will lose domestic and lab hot water service for the duration.

Temperature and Humidity Control:

·         The hot water outage impacts the comfort level of the air conditioning system. Building temperature and humidity controls will be closely monitored throughout the shutdown.

Key Dates:

    - May 23–24 – System shutdown and staged cooldown process.

    - May 28–June 7 – Infrastructure work including heat exchanger and valve replacements.

    - June 7–9 – System refill, pressure testing, and final restoration.

Tuesday, May 27, 2025

Due to a mechanical issue, the outdoor pool will remain closed. We anticipate being able to reopen it on June 11.

The indoor pool will open today as the temperature is over 75°F.

We will continue to share updates through our social media channels, website, and MyUMBC.

Thank you for your patience and understanding.