Xenophobia, or fear of the foreigner, has intensified in recent years in America, as seen, for example, through the increased anti-Asian sentiments under COVID-19. This conversation will reflect on the historical and contemporary forces that inform the discrimination against people of Asian descent as “perpetual foreigners.” Connecting the (often erased) Asian American experience to broader discussions of (im)migration and globalization, we will also explore helpful ways to challenge xenophobia and remedy its impact on mental health and well-being through artistic, scientific, and media practices.