DE Seminar: Undergraduate Student Presentations
Compton Camera Based Prompt Gamma Imaging Data for Proton Radiotherapy
The research utilizes MATLAB to simulate the egg chamber, border cells, and migratory cells. We captured heterogeneous cells of the egg chamber: including nurse, epithelial, and migratory border cells using interactions between cell membranes and arising via forces, including adhesive, repulsive, and spring forces. We developed the concept of neighborhoods to map interactions between cell boundaries. Furthermore, we used a volume force to include heterogeneously and realistically sized cells. After an initiation period where cells filled the chamber, we attempt to enact the migratory force, which stems from a chemical gradient signaling, allowing border cells to climb through nurse cells. We solved the force balance equation with Euler's step to capture progression in time. In MATLAB, we coded cell boundaries around cell centers to represent membranes while adapting parameters, equations, and coefficients in order to realistically simulate cell migration.
While research is ongoing, the research team has been able to progress in an understanding of the model and further incorporation of more complexities, striving to achieve a simulation that accurately mirrors real life observation of the migratory cells.