Shreyas Patel, CENG MS student

Title: 

Polycyclic Aromatic Hydrocarbon-Induced Disruption of Endothelial Permeability

Abstract:

Endothelial cells line the interior of vasculature and regulate nutrient exchange while preventing harmful compounds from invading surrounding tissue. Adherens and tight junctions form intercellular junctions that maintain cell-cell adhesion and regulate solute flux between systemic circulation and tissue. These intercellular junctions can be disrupted following exposure to polycyclic aromatic hydrocarbons (PAHs), causing increased permeability in the endothelial barrier. PAHs are ubiquitous pollutants in our surroundings as a consequence of rapid industrialization and heavy reliance on carbon-based fuels. PAH exposure is associated with a myriad of adverse health effects, ranging from skin and eye irritation to cardiovascular disease and cancer. Herein, the permeability of bovine pulmonary artery endothelial cells was examined in vitro following exposure to low molecular weight PAHs. Bovine endothelial barriers demonstrated an average, but not statistically significant, increase in permeability in fluorescein flux assays following exposure to naphthalene, anthracene, and pyrene. The presented data suggests these low molecular weight PAHs can exert an effect on endothelial barrier integrity and function but warrants further optimization to permeability assays and supplemental methods to elucidate the consequences of PAH exposure.

Agenda

11:30 am: Room Opens

12:00 pm : Presentation followed by questions from the audience.

~ 12:55 pm: After the questions from the public, the meeting will be closed for the committee discussion.

MS Thesis Defense: Shreyas Patel

https://umbc.webex.com/umbc/j.php?MTID=m41a06137e6aa9a4dece717009b6426a6

Wednesday, April 24, 2024 12:00 PM | 3 hours | (UTC-04:00) Eastern Time (US & Canada)

Meeting number: 2632 959 4594

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