UMBC’s Songon An is on a quest to explain how enzymes direct sugar metabolism through research with implications for cancer treatment. Scientists already know a great deal about how individual enzymes work in a test tube, but “once we move into the living cell system, we barely know about the enzymes,” says An, assistant professor of chemistry and biochemistry. With a new $1.5 million NIH grant, his lab is working to change that.

To explore how enzymes interact and form complex biochemical pathways in the body, An is using various biochemical and imaging techniques from biochemists and biophysicists. New, three-dimensional imaging techniques developed by Minjoung Kyoung, assistant professor of chemistry and biochemistry, will help examine the pathways at work inside living cells. A mathematical model developed by Hye-Won Kang, assistant professor of mathematics and statistics, supports the project. Read more